Principal Scientist, Biostatistics & Data Science

About This Role

At Roche, we are driven by a profound purpose: to prevent, stop, and cure diseases, ensuring everyone has access to healthcare today and for generations to come. We believe that true innovation stems from diverse perspectives and a culture where every voice matters. Here, you are embraced for your unique qualities, encouraged to express yourself, engage in open dialogue, and forge genuine connections. We foster an environment where you are valued, accepted, and respected, allowing you to thrive both personally and professionally. This foundational belief underpins our unwavering commitment to scientific excellence and patient impact.

As a Principal Scientist within our dynamic Statistics and Data Science team, you will play a pivotal role in shaping the future of medicine. You will leverage your deep expertise in biostatistics and advanced data science methodologies to drive the design, analysis, and interpretation of clinical studies and real-world data across various therapeutic areas. This is an unparalleled opportunity to lead critical initiatives, influence strategic decisions, and contribute directly to the development of life-changing therapies. You will be part of a collaborative, global network of experts, pushing the boundaries of scientific discovery and translating complex data into actionable insights that benefit patients worldwide.

Key Responsibilities

• Provide strategic statistical leadership and expertise for clinical development programs, from early-stage research through regulatory submission and post-market activities.
• Design innovative and robust clinical trials, including adaptive designs, Bayesian methods, and novel statistical approaches to optimize data collection and analysis.
• Lead the development and implementation of advanced statistical models and data science methodologies (e.g., machine learning, AI, predictive analytics) to extract insights from complex clinical, genomic, and real-world datasets.
• Oversee and perform rigorous statistical analyses, ensuring the integrity, accuracy, and interpretability of results.
• Collaborate effectively with cross-functional teams including clinicians, regulatory affairs, data management, and statistical programmers to ensure alignment on study design, analysis plans, and reporting.
• Contribute to the preparation of regulatory documents (e.g., INDs, NDAs, BLAs), scientific publications, and presentations, clearly communicating complex statistical concepts to diverse audiences.
• Drive the evaluation and adoption of new statistical software, tools, and methodologies to enhance efficiency and analytical capabilities.
• Mentor and provide technical guidance to junior statisticians and data scientists, fostering their professional growth and development.
• Act as a subject matter expert in internal and external scientific forums, representing Roche's statistical and data science capabilities.
• Ensure adherence to internal standard operating procedures, industry best practices, and regulatory guidelines (e.g., ICH, FDA, EMA).

Requirements & Qualifications

• Ph.D. in Biostatistics, Statistics, Data Science, or a closely related quantitative field with at least 8 years of relevant experience in the pharmaceutical or biotechnology industry; or an M.S. with at least 12 years of relevant experience.
• Proven track record of significant contributions to clinical development programs, including successful regulatory interactions and submissions.
• Extensive hands-on experience in the design, analysis, and reporting of clinical trials (Phase I-IV) and observational studies.
• Deep expertise in a broad range of statistical methodologies, including survival analysis, mixed models, Bayesian statistics, causal inference, and non-parametric methods.
• Proficiency in statistical programming languages such as R (preferred), SAS, and/or Python.
• Strong understanding of data science principles and practical experience with machine learning algorithms, predictive modeling, and handling large, complex datasets.
• Demonstrated ability to think strategically, innovate, and provide sound scientific judgment.
• Excellent written and verbal communication skills, with the ability to effectively convey complex statistical concepts to non-statisticians.
• Ability to work independently, manage multiple projects simultaneously, and thrive in a fast-paced, collaborative team environment.

Skills & Competencies

• Biostatistical Expertise
• Advanced Statistical Modeling
• Data Science & Machine Learning
• Clinical Trial Design & Analysis
• Statistical Programming (R, SAS, Python)
• Scientific Leadership & Mentorship
• Cross-functional Collaboration & Communication

What We Offer

At Roche, we believe that investing in our people is key to our success. We offer a vibrant and inclusive work environment where your contributions are recognized and celebrated. You will be empowered to make a tangible difference in patient lives, supported by a culture that encourages continuous learning, personal expression, and professional development. While specific benefits may vary, Roche is committed to providing a comprehensive package designed to support the well-being and growth of our employees.

• Opportunities for personal and professional growth
• A culture of open dialogue and genuine connections
• A diverse and inclusive work environment
• The chance to contribute to life-changing healthcare solutions
• Contact employer for full benefits information

How to Apply

If you are a visionary Principal Scientist eager to apply your statistical and data science expertise to transform patient care, we invite you to join Roche. Make your voice matter in our mission to prevent, stop, and cure diseases. Apply today to become a part of a team dedicated to scientific innovation and a healthier future for all.